Current Medicinal Chemistry

Atta-ur-Rahman, FRS
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK

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Dual Action-Based Approaches to Antibacterial Agents

Author(s): John B. Bremner, Joseph I. Ambrus and Siritron Samosorn

Affiliation: Department of Chemistry,University of Wollongong, Wollongong, NSW, 2522, Australia.

Keywords: Dual action antibacterials, bacterial resistance, dual action drugs, dual action prodrugs

Abstract:

This review collates and analyses recent work done on dual action approaches to tackling the mounting health problem of resistance by human pathogenic bacteria to antibacterial agents. In particular the areas reviewed include the use of two drugs in combination, dual action prodrugs, and dual action drugs (or hybrid drugs)

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Article Details

VOLUME: 14
ISSUE: 13
Page: [1459 - 1477]
Pages: 19
DOI: 10.2174/092986707780831168