AP-1 a Target for Cancer Prevention
Connie P. Matthews, Nancy H. Colburn and Matthew R. Young
Affiliation: Laboratory of Cancer Prevention,NCI-Frederick, Frederick Maryland, 21702, USA.
The transcription factor activator protein 1 (AP-1) plays a pivotal role in tumorigenesis. AP-1 activity is increased in multiple human tumor types. Inhibitors of AP-1 have been shown to block tumor promotion, transformation, progression and invasion. Chronic inflammation and tumor development are linked. AP-1 may act, in part, by perpetuating the inflammatory signal. AP-1 is a recognized molecular target of many antioxidant and anti-inflammatory chemopreventive compounds. This review focuses on the AP-1 family proteins as targets for chemoprevention.
Keywords: Fra-1, Jun, TAM67, tumor promotion, invasion, inflammation
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