AP-1 a Target for Cancer Prevention

Author(s): Connie P. Matthews, Nancy H. Colburn, Matthew R. Young.

Journal Name:Current Cancer Drug Targets

Volume 7 , Issue 4 , 2007

Abstract:

The transcription factor activator protein 1 (AP-1) plays a pivotal role in tumorigenesis. AP-1 activity is increased in multiple human tumor types. Inhibitors of AP-1 have been shown to block tumor promotion, transformation, progression and invasion. Chronic inflammation and tumor development are linked. AP-1 may act, in part, by perpetuating the inflammatory signal. AP-1 is a recognized molecular target of many antioxidant and anti-inflammatory chemopreventive compounds. This review focuses on the AP-1 family proteins as targets for chemoprevention.

Keywords: Fra-1, Jun, TAM67, tumor promotion, invasion, inflammation

Rights & PermissionsPrintExport

Article Details

VOLUME: 7
ISSUE: 4
Year: 2007
Page: [317 - 324]
Pages: 8
DOI: 10.2174/156800907780809723
Price: $58

Article Metrics

PDF: 3
HTML: 0
EPUB: 0
PRC: 0