Current Cancer Drug Targets

Ruiwen Zhang 
Texas Tech University Health Sciences Center
1300 Coulter Drive
Amarillo, TX 79106
USA

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AP-1 a Target for Cancer Prevention

Author(s): Connie P. Matthews, Nancy H. Colburn and Matthew R. Young

Affiliation: Laboratory of Cancer Prevention,NCI-Frederick, Frederick Maryland, 21702, USA.

Keywords: Fra-1, Jun, TAM67, tumor promotion, invasion, inflammation

Abstract:

The transcription factor activator protein 1 (AP-1) plays a pivotal role in tumorigenesis. AP-1 activity is increased in multiple human tumor types. Inhibitors of AP-1 have been shown to block tumor promotion, transformation, progression and invasion. Chronic inflammation and tumor development are linked. AP-1 may act, in part, by perpetuating the inflammatory signal. AP-1 is a recognized molecular target of many antioxidant and anti-inflammatory chemopreventive compounds. This review focuses on the AP-1 family proteins as targets for chemoprevention.

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Article Details

VOLUME: 7
ISSUE: 4
Page: [317 - 324]
Pages: 8
DOI: 10.2174/156800907780809723