Abstract
For management of pain, non-steroidal anti-inflammatory drugs (NSAIDs) play a major role. Use of NSAIDs is associated with toxicity, particularly in the gastrointestinal tract and kidney, whereas the use of COX-2 selective NSAIDs is associated with renal failure. Various approaches such as management of COX-1/COX-2 and 5-LOX/COX-2 inhibitors, use of natural products, formulation, drug modification and synthesis of new chemical entities in search of safer anti-inflammatory drugs reported in literature to overcome serious side effects of NSAIDs is summarized in this review. We have also reported recent findings in the area of synthesis of heterocyclic compounds such as pyrimidine, pyridine, thiazole, triazole, imidazole, oxazole, isooxazole, pyrazole , pyrazolidine, pyrole, acridine derivatives and other related heterocyclic compounds and their role as non-selective, COX-2 selective, LOX selective and COX/LOX dual, inhibitors.
Keywords: Heterocyclic compounds, anti-inflammatory agents, non-steroidal
Current Bioactive Compounds
Title: Heterocyclic Compounds as Anti-Inflammatory Agents
Volume: 3 Issue: 2
Author(s): Sham M. Sondhi, Monica Dinodia, Jaiveer Singh and Reshma Rani
Affiliation:
Keywords: Heterocyclic compounds, anti-inflammatory agents, non-steroidal
Abstract: For management of pain, non-steroidal anti-inflammatory drugs (NSAIDs) play a major role. Use of NSAIDs is associated with toxicity, particularly in the gastrointestinal tract and kidney, whereas the use of COX-2 selective NSAIDs is associated with renal failure. Various approaches such as management of COX-1/COX-2 and 5-LOX/COX-2 inhibitors, use of natural products, formulation, drug modification and synthesis of new chemical entities in search of safer anti-inflammatory drugs reported in literature to overcome serious side effects of NSAIDs is summarized in this review. We have also reported recent findings in the area of synthesis of heterocyclic compounds such as pyrimidine, pyridine, thiazole, triazole, imidazole, oxazole, isooxazole, pyrazole , pyrazolidine, pyrole, acridine derivatives and other related heterocyclic compounds and their role as non-selective, COX-2 selective, LOX selective and COX/LOX dual, inhibitors.
Export Options
About this article
Cite this article as:
Sondhi M. Sham, Dinodia Monica, Singh Jaiveer and Rani Reshma, Heterocyclic Compounds as Anti-Inflammatory Agents, Current Bioactive Compounds 2007; 3 (2) . https://dx.doi.org/10.2174/157340707780809554
DOI https://dx.doi.org/10.2174/157340707780809554 |
Print ISSN 1573-4072 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6646 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Ultrasonic Assisted Synthesis, Biological Evaluation, and Molecular Docking
of Chalcone-based 1,5-benzodiazepine as Potential Anticonvulsant
Agents
Current Enzyme Inhibition Subject Index To Volume 12
Current Pharmaceutical Design Therapeutic Targets for the Management of Peripheral Nerve Injury- Induced Neuropathic Pain
CNS & Neurological Disorders - Drug Targets Clinical Strategies for the Blockade of IL-18 in Inflammatory Bowel Diseases
Current Drug Targets Synthesis and Analysis of Anticonvulsant Activities of New 4-[2-(4- alkoxybenzylamino)ethyl]-2H-1,2,4-triazol-3(4H)-one Derivatives
Letters in Drug Design & Discovery Hydroxypyridinone Derivatives: A Fascinating Class of Chelators with Therapeutic Applications - An Update
Current Medicinal Chemistry Efficacy and Tolerability of Lacosamide for Focal Epileptic Patients: Study from Epilepsy Clinic in Makkah
CNS & Neurological Disorders - Drug Targets Nutrition and Bone Health: Its Relationship to Osteoporosis
Current Nutrition & Food Science Self-Regulatory Control and Habit Learning in the Development of Eating Disorders
Current Psychiatry Reviews Diabetes Gene Therapy: Potential and Challenges
Current Gene Therapy Novel Treatment and New Drugs in Epilepsy Treatment
Current Pharmaceutical Design Immunomodulatory Properties of Antibiotics
Current Molecular Pharmacology Phenotypic Screening Strategies for Neurodegenerative Diseases: A Pathway to Discover Novel Drug Candidates and Potential Disease Targets or Mechanisms
CNS & Neurological Disorders - Drug Targets Current Prodrug Design for Drug Discovery
Current Pharmaceutical Design The GABAergic System and the Gastrointestinal Physiopathology
Current Pharmaceutical Design Metallocarboxypeptidases and their Inhibitors: Recent Developments in Biomedically Relevant Protein and Organic Ligands
Current Medicinal Chemistry A Comprehensive Review on Recent advances in Synthesis & Pharmacotherapeutic potential of Benzothiazoles
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry The Interaction Potential of Retigabine (Ezogabine) with Other Antiepileptic Drugs
Current Clinical Pharmacology Ghrelin as a Neuroprotective and Palliative Agent in Alzheimer's and Parkinson's Disease
Current Pharmaceutical Design Neurological Disorders of Purine and Pyrimidine Metabolism
Current Topics in Medicinal Chemistry