The Pathophysiology of Uric Acid in Relation to Cardiovascular Disease

Author(s): Matiullah Naqibullah, Maiken J. Calberg, Erik Kjoller.

Journal Name: Current Cardiology Reviews

Volume 3 , Issue 2 , 2007

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Abstract:

Uric acid is produced by the degradation of purines, a process catalysed by xanthine oxidase, which is also responsible for the production of toxic free radicals. This provides a central link to the association between serum uric acid and myocardial ischemia, myocardial dysfunction and also non-cardiac dysfunction in patients with heart disease, mainly due to an impaired peripheral circulation. Uric acid can thus be considered a marker for pathophysiological mechanisms in patients with heart disease, and thus an explanation for S-uric acids prognostic importance. Inhibition of xanthine oxidase by allopurinol may possibly be used as a therapy for patients with heart disease in the future.

Keywords: Uric acid, xanthine dehydrogenase, cardiovascular disease, myocardial ischemia, endothelium, heart failure, ventricular dysfunction, allopurinol, metabolism, pathophysiological mechanism

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Article Details

VOLUME: 3
ISSUE: 2
Year: 2007
Page: [99 - 103]
Pages: 5
DOI: 10.2174/157340307780618406
Price: $58

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