Non-Homologous DNA End Joining in Anticancer Therapy
Elzbieta Pastwa and Mariusz Malinowski
Affiliation: Molecular Genetics Department,Medical University of Lodz, Mazowiecka 6/8, 92-215 Lodz, Poland.
Non-homologous DNA end joining (NHEJ) is the major pathway for the repair of double-strand breaks (DSBs) in human cells. Proteins involved in NHEJ pathway can become molecular targets in the treatment of cancer. Inhibition of this pathway leads to radio- and chemosensitization of cancer cells. This review will focus on the new therapeutic strategies for NHEJ pathway inhibition and their application in anticancer therapy.
Keywords: Non-homologous DNA end joining, NHEJ, DNA double-strand breaks, DSBs, DNA-dependent protein kinase, DNA-PK, chemosensitization, radiosensitization
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