Abstract
Biosensors are of great interest for their ability to monitor clinically important analytes such as blood gases, electrolytes, and metabolites. A classic example is to monitor the dynamics of blood-glucose levels for treating diabetes. However, the current practice, based on a three decade old technology, requires a drop of blood on a test strip, which is in dire need of replacement. The increasing demands and interests in developing implantable glucose sensors for treating diabetes has led to notable progress in this area, and various electrochemical sensors have been developed for intravascular and subcutaneous applications. However, implantations are plagued by biofouling, tissue destruction and infection around the implanted sensors and the response signals must be interpreted in terms of blood or plasma concentrations for clinical utility, rather than tissue fluid levels. This review focuses on the potentials and pitfalls of implantable electrochemical sensors and presents our opinions about future possibilities of such implantable devices with respect to biocompatibility issues, long-term calibration, and other aging effects on the sensors.
Keywords: Implantable electrochemical sensor, Glucose, Blood gases, Electrolyte, Biomaterials, In vivo monitoring, Biocompatibility, Device, Membrane
Current Medicinal Chemistry
Title: Implantable Electrochemical Sensors for Biomedical and Clinical Applications: Progress, Problems, and Future Possibilities.
Volume: 14 Issue: 8
Author(s): Chang Ming Li, Hua Dong, Xiaodong Cao, John H. T. Luong and Xueji Zhang
Affiliation:
Keywords: Implantable electrochemical sensor, Glucose, Blood gases, Electrolyte, Biomaterials, In vivo monitoring, Biocompatibility, Device, Membrane
Abstract: Biosensors are of great interest for their ability to monitor clinically important analytes such as blood gases, electrolytes, and metabolites. A classic example is to monitor the dynamics of blood-glucose levels for treating diabetes. However, the current practice, based on a three decade old technology, requires a drop of blood on a test strip, which is in dire need of replacement. The increasing demands and interests in developing implantable glucose sensors for treating diabetes has led to notable progress in this area, and various electrochemical sensors have been developed for intravascular and subcutaneous applications. However, implantations are plagued by biofouling, tissue destruction and infection around the implanted sensors and the response signals must be interpreted in terms of blood or plasma concentrations for clinical utility, rather than tissue fluid levels. This review focuses on the potentials and pitfalls of implantable electrochemical sensors and presents our opinions about future possibilities of such implantable devices with respect to biocompatibility issues, long-term calibration, and other aging effects on the sensors.
Export Options
About this article
Cite this article as:
Ming Li Chang, Dong Hua, Cao Xiaodong, T. Luong H. John and Zhang Xueji, Implantable Electrochemical Sensors for Biomedical and Clinical Applications: Progress, Problems, and Future Possibilities., Current Medicinal Chemistry 2007; 14 (8) . https://dx.doi.org/10.2174/092986707780362970
DOI https://dx.doi.org/10.2174/092986707780362970 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the treatment of chronic inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
An Interplay between Obesity and Inflammation in Gestational Diabetes Mellitus
Current Pharmaceutical Biotechnology Novel Concepts in the Pathogenesis and Management of Pediatric Hypertension
Current Pediatric Reviews Acute Effects of Oral Tofisopam on Plasma Concentration and Urinary Excretion of Uric Acid and Oxypurinol “Preliminary Communication”
Current Clinical Pharmacology Therapeutic Targeting of Cancers with Loss of PTEN Function
Current Drug Targets Decreased Vascular Repair and Neovascularization with Ageing: Mechanisms and Clinical Relevance with an Emphasis on Hypoxia- Inducible Factor-1
Current Molecular Medicine Tobacco Smoking and Association between Betel Nut Chewing and Metabolic Abnormalities Among Military Males: The CHIEF Study
Endocrine, Metabolic & Immune Disorders - Drug Targets CD44 - a New Cardiovascular Drug Target or Merely an Innocent Bystander?
Cardiovascular & Hematological Disorders-Drug Targets Kinin Receptors in Vascular Biology and Pathology
Current Vascular Pharmacology Structural Bioinformatic Approaches to the Discovery of New Antimycobacterial Drugs
Current Pharmaceutical Design Insulin Resistance and Polycystic Ovary Syndrome
Current Pharmaceutical Design Molecules of Parasites as Immunomodulatory Drugs
Current Topics in Medicinal Chemistry Treatment of Inflammatory and Paraproteinemic Neuropathies
Current Drug Targets - Immune, Endocrine & Metabolic Disorders Preparation of Activated Disposable Pencil Graphite Electrode for the Selective and Sensitive Determination of a Fluoroquinolone Antibiotic: Levofloxacin
Current Pharmaceutical Analysis 4(1H)-Pyridone and 4(1H)-Quinolone Derivatives as Antimalarials with Erythrocytic, Exoerythrocytic, and Transmission Blocking Activities
Current Topics in Medicinal Chemistry Endothelial Function Assessment in Complicated Hypertension
Current Pharmaceutical Design Radiation-Induced Extracranial Carotid Stenosis
Vascular Disease Prevention (Discontinued) Predictive Genomics DNA Profiling for Athletic Performance
Recent Patents on DNA & Gene Sequences Impaired Awareness of Hypoglycaemia in Insulin-treated Type 2 Diabetes Mellitus
Current Diabetes Reviews Recent Advances in Nasal Drug Delivery Using Natural Polymers
Current Drug Therapy Medium-Chain Dehydrogenases with New Specificity: Amino Mannitol Dehydrogenases on the Azasugar Biosynthetic Pathway
Protein & Peptide Letters