The Effect of Statins on Postprandial Lipemia

Author(s): Genovefa D. Kolovou, Katherine K. Anagnostopoulou, Klelia D. Salpea, Stella S. Daskalopoulou, Dimitri P. Mikhailidis.

Journal Name: Current Drug Targets

Volume 8 , Issue 4 , 2007

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Abstract:

Several studies showed that postprandial plasma triglyceride (TG) concentrations are higher in patients with coronary heart disease. TG-rich lipoprotein remnants accumulated in the postprandial state are involved in atherogenesis and in events leading to thrombosis. Lipid lowering drugs, such as 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors (statins) are of significant benefit in the primary and secondary prevention of atherosclerosis. Statins can decrease total cholesterol and low density lipoprotein cholesterol as well as TG concentrations and improve postprandial lipoprotein metabolism. Since abnormal postprandial lipemia is associated with pathological conditions, its treatment is relevant. This review considers the effect of statins on postprandial lipemia.

Keywords: Postprandial lipemia, statins, triglycerides, coronary heart disease

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Article Details

VOLUME: 8
ISSUE: 4
Year: 2007
Page: [551 - 560]
Pages: 10
DOI: 10.2174/138945007780362809
Price: $58

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