Current Cancer Drug Targets

Ruiwen Zhang 
Texas Tech University Health Sciences Center
1300 Coulter Drive
Amarillo, TX 79106
USA

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Oncolytic Viruses Driven by Tumor-Specific Promoters

Author(s): Jayson Hardcastle, Kazuhiko Kurozumi, E. Antonio Chiocca, Balveen Kaur.

Abstract:

Oncolytic viruses can selectively replicate in and lead to tumor cell lysis with minimal infection/replication potential in adjoining non-neoplastic tissue. Because of paramount safety concerns, first-generation oncolytic viruses were designed to be significantly attenuated in their lytic potential. Results from recent clinical trials have revealed the safety of this approach, but have underscored the urgency for design and testing of more tumor-selective and -potent viruses to realize the full therapeutic potential of this revolutionary treatment modality. With the discovery of various molecular/genetic changes associated with neoplasia, tumor-specific transcriptional targeting of viral virulence is being tapped to generate tumor- and tissue-specific variants. This review will focus on the various strategies exploited to generate viruses whose virulence is governed by tumorspecific transcriptional events.

Keywords: Oncolytic viruses, adenovirus, HSV-1, cancer, transcriptional regulation, promoter

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Article Details

VOLUME: 7
ISSUE: 2
Year: 2007
Page: [181 - 189]
Pages: 9
DOI: 10.2174/156800907780058880
Price: $58