Current Cancer Drug Targets

Ruiwen Zhang 
Texas Tech University Health Sciences Center
1300 Coulter Drive
Amarillo, TX 79106
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Mechanisms Used by Human Papillomaviruses to Escape the Host Immune Response

Author(s): Shreya Kanodia, Laura M. Fahey, W. Martin Kast.

Abstract:

The greatest risk factor for the development of cervical and other cancers that have been linked to the human papillomavirus (HPV) family is the persistence of the virus. To persist for the decades required to develop HPV-related cancers, the virus must escape host immunity. HPV is a simple DNA virus that has evolved to escape immune attack by a combination of stealth and interference. This review focuses on the mechanisms by which HPV can evade recognition by the host immune system.

Keywords: Papilloma virus, tumor immunology, immunotherapy, cancer

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Article Details

VOLUME: 7
ISSUE: 1
Year: 2007
Page: [79 - 89]
Pages: 11
DOI: 10.2174/156800907780006869