Abstract
Melanoma is the most aggressive form of skin cancer and advantages stages are inevitably resistant to conventional therapeutic agents. In particular, the inability of undergo apoptosis in response to chemotherapy and other external stimuli poses a selective advantage for tumor progression, metastasis formation as well as resistance to therapy in melanoma. Herein, we will review the discovery of MDR transporters and the apoptotic mechanisms used by melanoma cells. Furthermore, the novel strategies to overcome tumor chemoresistance will also discuss. In particular, we will review the cancer stem cell hypothesis and how the failure of MDR reversal agents might increase the therapeutic index of substrate antineoplastic agents.
Keywords: multi-drug resistance (MDR) Transporter, dacarbazine, ATP binding cassette (ABC) transporters, apoptosis, Chemoresistance
Current Medicinal Chemistry
Title: Drug Resistance in Melanoma: New Perspectives
Volume: 14 Issue: 4
Author(s): Caterina A.M. La Porta
Affiliation:
Keywords: multi-drug resistance (MDR) Transporter, dacarbazine, ATP binding cassette (ABC) transporters, apoptosis, Chemoresistance
Abstract: Melanoma is the most aggressive form of skin cancer and advantages stages are inevitably resistant to conventional therapeutic agents. In particular, the inability of undergo apoptosis in response to chemotherapy and other external stimuli poses a selective advantage for tumor progression, metastasis formation as well as resistance to therapy in melanoma. Herein, we will review the discovery of MDR transporters and the apoptotic mechanisms used by melanoma cells. Furthermore, the novel strategies to overcome tumor chemoresistance will also discuss. In particular, we will review the cancer stem cell hypothesis and how the failure of MDR reversal agents might increase the therapeutic index of substrate antineoplastic agents.
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Cite this article as:
Caterina A.M. La Porta , Drug Resistance in Melanoma: New Perspectives, Current Medicinal Chemistry 2007; 14 (4) . https://dx.doi.org/10.2174/092986707779941078
DOI https://dx.doi.org/10.2174/092986707779941078 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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