Current Medicinal Chemistry

Atta-ur-Rahman, FRS
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK

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Drug Resistance in Melanoma: New Perspectives

Author(s): Caterina A.M. La Porta.

Abstract:

Melanoma is the most aggressive form of skin cancer and advantages stages are inevitably resistant to conventional therapeutic agents. In particular, the inability of undergo apoptosis in response to chemotherapy and other external stimuli poses a selective advantage for tumor progression, metastasis formation as well as resistance to therapy in melanoma. Herein, we will review the discovery of MDR transporters and the apoptotic mechanisms used by melanoma cells. Furthermore, the novel strategies to overcome tumor chemoresistance will also discuss. In particular, we will review the cancer stem cell hypothesis and how the failure of MDR reversal agents might increase the therapeutic index of substrate antineoplastic agents.

Keywords: multi-drug resistance (MDR) Transporter, dacarbazine, ATP binding cassette (ABC) transporters, apoptosis, Chemoresistance

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Article Details

VOLUME: 14
ISSUE: 4
Year: 2007
Page: [387 - 391]
Pages: 5
DOI: 10.2174/092986707779941078
Price: $58