Current Neurovascular Research

Prof. Kenneth Maiese
Neurology and Neurosciences UMDNJ
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Recombinant Human Growth Hormone in Abstinent Androgenic-Anabolic Steroid Use: Psychological, Endocrine and Trophic Factor Effects

Author(s): Michael R. Graham, Bruce Davies, Andrew Kicman, David Cowan, David Hullin and Julien S. Baker

Affiliation: Department of Exercise and Health Science, School of Applied Science, University of Glamorgan, Pontypridd,Wales, United Kingdom.


This study examined whether six days recombinant human growth hormone (rhGH) affected psychological profile in an abstinent androgenic-anabolic steroid (AAS) abusing group, compared with an abstinent AAS control group. Male subjects (n = 48) were assigned in a random fashion into one of two groups: (1): (n =24) control group (C); (2): (n =24) rhGH group (GH). A hospital anxiety scale (HADS) questionnaire was completed by all subjects. Physiological responses investigated included anthropometry. Biochemical markers examined included; serum glucose, sodium, urea, lipid profile, high sensitivity C-reactive protein (hsCRP), homocysteine (HCY), tetra-iodothyronine (T4), thyroid stimulating (TSH), luteinising (LH) and follicle stimulating (FSH) hormones, testosterone (T), prolactin (PRL), cortisol and insulin like growth factor-1 (IGF-I). HADS questionnaire significantly decreased in both anxiety (A) and depression (D) symptoms within GH (P < 0.017) and compared with C (P < 0.05). Body mass index (BMI) and fat-free mass index (FFMI) significantly increased (both P < 0.017) while body fat significantly decreased within GH (P < 0.017). IGF-I significantly increased within GH (P < 0.017) and significantly increased compared with C (P < 0.05). Serum sodium significantly increased (P < 0.017) and serum HCY, hsCRP, TSH and T4, significantly decreased within GH (all P < 0.017). PRL significantly increased and T4 significantly decreased compared with C (both P < 0.05). The findings of this study suggest that short term use of rhGH has beneficial effects on mental state in individuals who were previous abusers of AAS and appeared to have a beneficial effect on cardiovascular risk markers associated with adverse mental health.

Keywords: Anxiety, body composition, cardiovascular, depression, psychology, insulin-like growth factor-I

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Article Details

Page: [9 - 18]
Pages: 10
DOI: 10.2174/156720207779940699