Current Gene Therapy

Ignacio Anegon
Director INSERM UMR 1064-Center for Research in Transplantation and Immunology
CHU de Nantes. 30, boulevard
Nantes
France

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Gene Modified Cell Transplantation for Vascular Regeneration

Author(s): Satoshi Murasawa, Takayuki Asahara.

Abstract:

Cell Transplantation is one of the powerful tools to ameliorate the capillary flow in ischemic condition. EPC (Endothelial Progenitor Cell) was identified in adult peripheral blood and thought to be a suitable candidate for cell transplantation. Also, gene therapy is already promising choice for enhancing angiogenic property. The combination of cell transplantation and gene therapy should be more effective way to regenerate vasculature in ischemic region. Recently, several research reports have come out regarding gene modified cell transplantation. We will mainly focus on the background of EPC, and then gene modified EPC findings in this review.

Keywords: Endothelial Progenitor Cell (EPC), Gene modified cell therapy, VEGF, TERT, Vasculogenesis

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Article Details

VOLUME: 7
ISSUE: 1
Year: 2007
Page: [1 - 6]
Pages: 6
DOI: 10.2174/1566523210707010001