PEGylated Dendritic Architecture for Development of a Prolonged Drug Delivery System for an Antitubercular Drug

Author(s): P. Vijayaraj Kumar, Hrushikesh Agashe, Tathagata Dutta, Narendra K. Jain.

Journal Name: Current Drug Delivery

Volume 4 , Issue 1 , 2007

Submit Manuscript
Submit Proposal

Abstract:

The present study was aimed at developing and exploring the use of PEGylated poly (propylene imine) dendritic architecture for the delivery of an anti-tuberculosis drug, rifampicin. For this study, PEGylated poly(propylene imine) dendritic architecture was synthesized and loaded with rifampicin. Various physicochemical and physiological parameters UV, IR, NMR, TEM, DSC, drug entrapment, drug release and hemolytic toxicity of both PEGylated and non- PEGylated systems were determined and compared. The PEGylation of the systems was found to have increased their drug-loading capacity, reduced their drug release rate and hemolytic toxicity. The systems were found suitable for prolonged delivery of rifampicin.

Keywords: Dendrimers, PEGylation, micelles, rifampicin, prolonged release

Rights & PermissionsPrintExport Cite as


Article Details

VOLUME: 4
ISSUE: 1
Year: 2007
Page: [11 - 19]
Pages: 9
DOI: 10.2174/156720107779314794

Article Metrics

PDF: 20