Anti-Infective Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Anti-Infective Agents)


Extended-Spectrum Cephalosporinases in Enterobacteriaceae

Author(s): Hedi Mammeri, Patrice Nordmann.


Extended-spectrum AmpC β-lactamases are derived from chromosomal cephalosporinases by amino acid deletion, insertion and replacement. These structural changes are responsible for an increased catalytic efficiency against extended- spectrum cephalosporins, such as ceftazidime, cefotaxime, cefepime, and cefpirome. An overview of the molecular and biochemical characterization of these identified β-lactamases in Enterobacteriaceae is provided. The structural modifications that account for the broadening substrate specificity and the phenotypes of resistance of the clinical isolates are detailed.

Keywords: ESAC, extended-spectrum cephalosporinase, cefepime, ceftazidime

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Article Details

Year: 2007
Page: [71 - 82]
Pages: 12
DOI: 10.2174/187152107779314133