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Combinatorial Chemistry & High Throughput Screening

Editor-in-Chief

ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

Synthesis of Tetrahydrobenzimidazo[1,2-b]quinazolin-1(2H)-one and Tetrahydro-1,2,4-triazolo[5,1-b]quinazolin-8(4H)-one Ring Systems Under Solvent-Free Conditions

Author(s): Ahmad Shaabani, Elham Farhangi and Abbas Rahmati

Volume 9, Issue 10, 2006

Page: [771 - 776] Pages: 6

DOI: 10.2174/138620706779026060

Price: $65

Abstract

Tetraheterocyclic benzimidazo[1,2-a]quinazolin-4(1H)-one and tetrahydro-1,2,4-triazolo[5,1-b]quinazolin- 8(4H)-one were synthesized in relatively high yields by the condensation reaction of an aldehyde and a cyclic β-diketone with 2-aminobenzothiazole, 2-aminobenzimidazole or 3-amino-1,2,4-triazole without using any catalyst under solventfree conditions.

Keywords: 2-Aminobenzimidazole, 2-aminobenzothiazole, 3-amino-1,2,4-triazole, cyclic β-diketone, Biginelli-like reaction, multicomponent reaction


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