Preparation and Oxidation Chemistry of the Catechol Estrogens: Relevance to Estrogen-Related Carcinogenesis and Potential for Drug Design

Author(s): Alessandro Pezzella, Liliana Lista, Alessandra Napolitano, Marco d'Ischia.

Journal Name:Current Bioactive Compounds

Volume 2 , Issue 4 , 2006

Abstract:

In this review we will briefly survey the oxidation chemistry of the catechol estrogens (2-hydroxy- and 4- hydroxyestradiol, 2-OH-E and 4-OH-E) as a result of the research carried out in the authors laboratory and other centers during the past decade. The central focus of the paper will be on the main pathways of oxidative modification and their possible relevance to the mechanisms of estrogen-related carcinogenesis. The chemical bases underlying the different reactivity and toxicity of 2-hydroxy and 4-hydroxyestradiol will be addressed. The value of catechol estrogen oxidation in the discovery of novel functionalized or modified steroidal scaffolds of potential pharmaceutical interest will be also briefly highlighted.

Keywords: Estradiol, catechol estrogen, tyrosinase, peroxidase, carcinogenesis, oxidation, o-quinone(s)

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Article Details

VOLUME: 2
ISSUE: 4
Year: 2006
Page: [445 - 451]
Pages: 7
DOI: 10.2174/157340706778992555
Price: $58