Current Hypertension Reviews

Prof. Kazuomi Kario
Jichi Medical University
School of Medicine


Isolated Systolic Hypertension: Epidemiology, Pathogenesis and Treatment

Author(s): Danny Dvir, Yehonatan Sharabi, Ehud Grossman.


Isolated systolic hypertension (ISHTN) is rapidly rising in prevalence, largely due to the advancing age of the population and it will soon become the most common type of hypertension. Untreated patients with merely borderline ISHTN already have a 50% grater risk for cardiovascular complications. Several studies demonstrated that treating ISHTN is beneficial. However, such treatment could cause a potential harm by further reducing the non-elevated diastolic blood pressure; a theory that underlies the controversial “J curve”. In this review, we summarize the epidemiology and pathogenesis of this disorder according to the latest studies, with special emphasis on when, and to what goal, blood pressure should be lowered, and with which medications.

Keywords: diastolic blood pressure (DBP), systolic blood pressure (SBP), angiotensin converting enzyme inhibitors, diuretics, cardiovascular events

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Article Details

Year: 2006
Page: [271 - 274]
Pages: 4
DOI: 10.2174/157340206778742520
Price: $58