Anti-Cancer Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Michelle Prudhomme  
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France

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Stimuli-Sensitive Polymeric Micelles as Anticancer Drug Carriers

Author(s): Vijay A. Sethuraman, You Han Bae, Vijay T. Sethuraman, Kun Na.

Abstract:

Amphiphilic block copolymers often form core-shell type micelles by self-organization of the blocks in an aqueous medium or under specific experimental conditions. Polymeric micelles constructed from these polymers that contain a segment whose physical or chemical properties respond to small changes in environmental conditions are collectively called ‘stimuli-sensitive ’ micelles. This class of nano-scaled constructs has been investigated as a promising anticancer drug carrier because the micelles are able to utilize small environmental changes and modify drug release kinetics, biodistribution and the interactions with tissues and cells. This review summarizes the recent progress in stimuli-sensitive micelles for tumor chemotherapy, particularly for those responding to hyperthermic conditions, tumor pH and endosomal/ lysosomal pH.

Keywords: Micelles, self-organization, stimuli-sensitive, hyperthermic conditions, tumor pH, endosomal/lysosomal pH

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Article Details

VOLUME: 6
ISSUE: 6
Year: 2006
Page: [525 - 535]
Pages: 11
DOI: 10.2174/187152006778699068
Price: $58