Integrins and Cancer: Gene Expression, Epigenetics and Metastasis

Author(s): T. Stuardi, S. M.O. Phipps, T. O. Tollefsbol.

Journal Name: Current Genomics

Volume 7 , Issue 5 , 2006

Abstract:

Integrins are composed of a variety of binding subunits that are responsible for interacting with the extracellu-lar matrix and intracellular signaling pathways. Among their various functions, integrins have the ability to augment cellu-lar adhesion, influence cytoskeletal architecture, activate tyrosine kinase and affect cell survival. Many investigations have demonstrated a correlation between the regulation of integrin expression and tumor invasiveness and proliferation. Integrins affect transcription factors Twist and HoxD3, epigenetic regulation, matrix metalloproteinases, insulin-like growth factors, integrin-linked kinases and adherens junctions, which are all important components of tumorigenicity. Cancer cells modify their functional genomic composition thereby altering integrin expression. Understanding the rela-tionship between integrin expression and tumor activities could provide an important strategy for cancer treatment.

Keywords: Integrin, cancer, Twist, ILK, MMP, epigenetic, HoxD3

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Article Details

VOLUME: 7
ISSUE: 5
Year: 2006
Page: [323 - 331]
Pages: 9
DOI: 10.2174/138920206778604377
Price: $58

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