Cimicifugae Rhizoma: From Origins, Bioactive Constituents to Clinical Outcomes

Author(s):

Journal Name: Current Medicinal Chemistry

Volume 13 , Issue 24 , 2006

Become EABM
Become Reviewer

Abstract:

Cimicifugae Rhizoma, mainly originated from C. acerina, C. dahurica, C. foetida, C. heracleifolia, C. racemosa and C. simplex, has long been used in traditional medicine system. During the past 45 years, a lot of efforts have been dedicated to the studies on their bioactive constituents, pharmacological effects and clinical uses, and a variety of biological activities including relief of hot flash, anti-osteoporosis, anti-human immunodeficiency virus (HIV), antiinflammatory, antidiabetes, antimalaria and vasoactive property have been discovered. Although C. racemosa is widely applied to relieve menopause symptoms in clinic for its hormonal-like action, meaningfully, no estrogenic effect was confirmed up to date. The purpose of this paper is to systematically highlight these achievements and the further therapeutic potential. The origins and distributions of the rhizome are simply listed and phytochemical aspects including over 200 compounds mainly belonging to cycloartane-type triterpenoids have been summarized. The pharmacological characterizations, especially, as a clinically effective phytomedicine, the effects of the rhizoma on menopause symptoms and the clinical applications including possible mechanism have been reviewed in detail. Various in vivo, in vitro studies on the anti-bone resorption effects of the triterpenoids, together with structure-activity relationships are also incorporated to explore the therapeutic potential on osteoporosis, a major public health threat for postmenopausal women.

Keywords: Cimicifugae rhizoma, phytochemicals, triterpenoids, bioactivities, anti-menopause symptoms, anti-osteoporosis

Rights & PermissionsPrintExport Cite as


Article Details

VOLUME: 13
ISSUE: 24
Year: 2006
Page: [2927 - 2951]
Pages: 25
DOI: 10.2174/092986706778521869
Price: $58

Article Metrics

PDF: 8