Particulate Systems as Adjuvants and Carriers for Peptide and Protein Antigens

Author(s): Ming Tao Liang , Nigel M. Davies , Joanne T. Blanchfield , Istvan Toth .

Journal Name: Current Drug Delivery

Volume 3 , Issue 4 , 2006

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Abstract:

The most common feature for antigen-delivery systems is their particulate nature. Together with a certain depot effect, it is the particulate nature that primarily dictates whether the antigen-delivery system will be successful in inducing a certain type and strength of immune response. In this article, we will summarize recent data on particulate delivery systems for peptide and protein antigens with a main focus on lipid or polymer-based particles, all of which possess high potential as both preventive and therapeutic vaccines for parenteral, nasal, and possibly oral administration.

Keywords: Vaccine delivery, particulate delivery system, peptide or protein antigen, lipid, polymer

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Article Details

VOLUME: 3
ISSUE: 4
Year: 2006
Page: [379 - 388]
Pages: 10
DOI: 10.2174/156720106778559029
Price: $58

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