Anti-Infective Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Anti-Infective Agents)

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Antisense DNA and RNA: Potential Therapeutics for Viral Infection

Author(s): Ji Yuan, Travis Lim, Zhen Liu, Dexin Qiu, Brian Wong, Honglin Luo, Xiaoning Si, Bruce McManus, Decheng Yang.

Abstract:

Antisense DNA and RNA are valuable tools to inhibit expression of a target gene in a sequence-specific manner. These molecules are not only widely used for gene functional study but also for therapeutic purpose. The strategy for therapeutics is attributed to its specific inhibition of gene expression of pathogens or disease-causing genes. Three types of anti-mRNA strategies can be distinguished, including antisense oligodeoxynucleotide (AODN), nucleic acid enzymes, and double-stranded small interfering RNA (siRNA). In this article we overview the basic principles of AODN and siRNA and then focus on their potential applications in antiviral therapy including our own data on coxsackieviral infection, a common pathogen of human myocarditis. In addition, we also briefly discuss the problems and difficulties in these drug developments, which need to be overcome to achieve the final goal in clinical application.

Keywords: Antisense oligodeoxynucleotide, small interfering RNA, antiviral agents, coxsackievirus B3

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Article Details

VOLUME: 5
ISSUE: 4
Year: 2006
Page: [367 - 377]
Pages: 11
DOI: 10.2174/187152106778520460
Price: $58