Current Organic Chemistry

Atta-ur-Rahman , FRS
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK

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Asymmetrically Modified Nickel Catalyst for the Enantio-Differentiating Hydrogenation of Prochiral Ketones

Author(s): T. Osawa, T. Harada, O. Takayasu.

Abstract:

The state of the art for the enantio-differentiating hydrogenation over an asymmetrically modified nickel catalyst is reviewed along with the background development of the catalyst. An enantioselectivity up to 98% was obtained for the hydrogenation of β-functionalized ketones. The durability of the enantioselectivity was significantly improved using an in-situ-modified nickel powder catalyst (80-90% enantioselectivity for over 20 runs). Recent mechanistic investigations based on surface science are also summarized for the discussion of the enantio-differentiating model.

Keywords: bitartrate molecules, Enantio-Differentiation Model, non-selective hydrogenation, 2-alkanones, Supported Ni catalysts

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Article Details

VOLUME: 10
ISSUE: 13
Year: 2006
Page: [1513 - 1531]
Pages: 19
DOI: 10.2174/138527206778249676
Price: $58