Cytotoxic Potential of Phenothiazines

Author(s): Noboru Motohashi, Masami Kawase, Kazue Satoh, Hiroshi Sakagami.

Journal Name: Current Drug Targets

Volume 7 , Issue 9 , 2006

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Abstract:

Phenothiazines, a kind of sulfur-containing tricyclic compounds, have diverse biological activities including tranquilizer, antibacterial, antitumor and antihelmintic activities due to the relatively lower cytotoxicity. Phenothiazines have been used for clinical treatments as psychotropics. In contrast to the psychotropic preparations, their information of other biological activities of phenothiazines and their related compounds has been limited. This review article summarizes the interaction with DNA (using quantum calculation), antitumor activity, differentiation or apoptosis-inducing activity, tumor necrosis factor (TNF)-induction, antiproliferative activity, radical scavenging activity, antimutagenic activity, antiplasmid activity, antibacterial activity, reversal of multidrug resistance (MDR), blast transformation activity of phenothiazines, benz[c]acridines and benzo[a]phenothiazines.

Keywords: Antitumor, Radical Scavenging Activity, Tumor Necrosis Factor (TNF), CPZ-nucleotide systems, AIDS, Blast Transformation

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Article Details

VOLUME: 7
ISSUE: 9
Year: 2006
Page: [1055 - 1066]
Pages: 12
DOI: 10.2174/138945006778226624
Price: $58

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