Hypericin Lights Up the Way for the Potential Treatment of Nasopharyngeal Cancer by Photodynamic Therapy

Author(s): Malini Olivo, Hong-Yan Du, Boon-Huat Bay.

Journal Name: Current Clinical Pharmacology

Volume 1 , Issue 3 , 2006

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Abstract:

Photodynamic therapy (PDT) involves the administration of a photosensitizer followed by light irradiation with a specific wavelength, giving rise to irreversible tissue destruction. Hypericin, a herbal extract derived from Hypericum perforatum or St. Johns Wort, has minimal toxicity but exhibits potent photo-damaging effects in the presence of light. Hypericin is known to generate a high yield of singlet oxygen and other reactive oxygen species that are associated with photo-oxidative cellular damage. The application of PDT with hypericin for the treatment of cancers such as recurrent mesothelioma and skin cancer has been validated in clinical trials. This mini-review focuses on the investigative studies of hypericin as a potential photodynamic agent in the treatment of nasopharyngeal cancer (NPC) in in vitro and in vivo models. NPC is an enigmatic tumor with a multifactorial etiology and a high incidence in the populations of Southern China.

Keywords: Photosensitizer, photo-toxicity, hypericin, nasopharyngeal carcinoma

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Article Details

VOLUME: 1
ISSUE: 3
Year: 2006
Page: [217 - 222]
Pages: 6
DOI: 10.2174/157488406778249370
Price: $58

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PDF: 6