Current Computer-Aided Drug Design

Subhash C. Basak
Departments of Chemistry, Biochemistry & Molecular Biology University of Minnesota Duluth
Duluth, MN 55811
USA

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Cancer and Aids: New Trends in Drug Design and Chemotherapy

Author(s): Carlton Anthony Taft, Carlos Henrique Tomich de Paula da Silva.

Abstract:

We present a comprehensive but not exhaustive review of new trends in drug discovery and targets for cancer and AIDS which begins by highlighting the different historical stages of drug discovery from clinical diagnosis, natural compounds, serendipity and chemotherapy to the present age of modern experimental and computational techniques. The current state of the art of computer-aided drug design and selected recent applications to Cancer and AIDS are discussed. Novel targets and drugs in Cancer and AIDS are analyzed. In conclusion, future perspectives for drug discovery, design and therapeutics in cancer and AIDS are presented.

Keywords: HIV-1, non-nucleoside reverse transcriptase inhibitors (NNRTIs), chemokine co-receptors, anti-VEGF antibody, molecular modeling (MM)

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Article Details

VOLUME: 2
ISSUE: 3
Year: 2006
Page: [307 - 324]
Pages: 18
DOI: 10.2174/157340906778226382
Price: $58