Levocetirizine: An Update

Author(s): Garry M. Walsh.

Journal Name: Current Medicinal Chemistry

Volume 13 , Issue 22 , 2006


Histamine plays a prominent and diverse role in the pathophysiology of allergic disease and therapeutic intervention is therefore typically focused on blocking the effects of this biogenic amine. A new antihistamine, levocetirizine, is the R-enantiomer of cetirizine dihydrochloride and like its parent compound undergoes minimal hepatic metabolism. Levocetirizine has pharmacodynamically and pharmacokinetically favourable characteristics, including high bioavailability, rapid onset of action, limited distribution and a low degree of metabolism. Clinical trials indicate that it is safe and effective for the treatment of allergic rhinitis and chronic urticaria with a minimal number of untoward effects. Furthermore, several recent studies have demonstrated that, in addition to its being a potent antihistamine, levocetirizine has several anti-inflammatory effects that are observed at clinically relevant concentrations that may enhance its therapeutic benefit.

Keywords: Levocetirizine, antihistamine, allergy, anti-inflammatory

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Article Details

Year: 2006
Page: [2711 - 2715]
Pages: 5
DOI: 10.2174/092986706778201594
Price: $65

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