Biopharmaceutical Therapeutics for Asthma Remodeling

Author(s): A. M. Das, D. E. Griswold, T. J. Torphy, L. Li.

Journal Name: Current Pharmaceutical Design

Volume 12 , Issue 25 , 2006

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Abstract:

Current asthma therapy is aimed at controlling disease symptoms. A subset of asthma patients remains symptomatic despite optimal therapy indicating that an unmet medical need exists for these patients. Innovative therapeutics are needed to treat the unmet need in asthma and biopharmaceutical approaches may provide an opportunity for identifying these agents. It is proposed that airway remodeling contributes to asthma symptoms and this feature of disease pathology may be a target for future therapies. The current review focuses on the contribution of one feature of airway remodeling, subepithelial fibrosis, towards disease and highlights some of the mechanisms that may contribute to this feature of airway remodeling. Further, some potential molecular targets are identified for consideration for therapeutic intervention.

Keywords: Biopharmaceuticals, asthma, remodeling, unmet need

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Article Details

VOLUME: 12
ISSUE: 25
Year: 2006
Page: [3233 - 3240]
Pages: 8
DOI: 10.2174/138161206778194097
Price: $58

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