Round and Round we Go: Cyclic Peptides in Disease

Author(s): John Matsoukas, Vasso Apostolopoulos, Eliada Lazoura, George Deraos, Minos-Timotheos Matsoukas, Maria Katsara, Theodore Tselios, Spyros Deraos.

Journal Name: Current Medicinal Chemistry

Volume 13 , Issue 19 , 2006

Abstract:

There is a need for novel drugs for the treatment of infectious diseases, autoimmunity and cancer. Cyclic peptides constitute a class of compounds that have made crucial contributions to the treatment of certain diseases. Penicillin, Vancomycin, Cyclosporin, the Echinocandins and Bleomycin are well-known cyclic peptides. Cyclic peptides, compared to linear peptides, have been considered to have greater potential as therapeutic agents due to their increased chemical and enzymatic stability, receptor selectively, and improved pharmacodynamic properties. They have been used as synthetic immunogens, transmembrane ion channels, antigens for Herpes Simplex Virus, potential immunotherapeutic vaccines for diabetes and Experimental Autoimmune Encephalomyelitis - an animal model of Multiple Sclerosis, as inhibitors against α-amylase and as protein stabilizers. Herein, we review important cyclic peptides as therapeutic agents in disease.

Keywords: Gonadotropin Releasing Hormone, Thrombin, Angiotensin II, Myelin epitopes, Cyclic peptides

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Article Details

VOLUME: 13
ISSUE: 19
Year: 2006
Page: [2221 - 2232]
Pages: 12
DOI: 10.2174/092986706777935113
Price: $58

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