Anti-Cancer Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Michelle Prudhomme  
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France

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Targeting Focal Adhesion Kinase in Neuroblastoma

Author(s): Lauren Gillory, Elizabeth A. Beierle.

Abstract:

Neuroblastoma is the most common extracranial solid tumor encountered in children, and continues to carry a dismal prognosis. Focal adhesion kinase (FAK) has been shown to be upregulated in a number of human tumors and is related to tumor virulence and patient prognosis. We have demonstrated FAK expression in human neuroblastoma cell lines and tumors, and have shown that FAK is important for neuroblastoma tumor cell viability. We have also demonstrated that FAK inhibition through a number of different methods results in decreased neuroblastoma survival both in vitro and in vivo. The current review addresses the merit of further exploring FAK inhibition as a novel treatment for neuroblastoma.

Keywords: C4, FAK, neuroblastoma, NVP-TAE226, Y15, Cellular Adhesion, VEGFR, MHC, NCAM, MYCN, SKP, chloropyramine hydrochloride, tumor

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Article Details

VOLUME: 10
ISSUE: 10
Year: 2010
Page: [714 - 721]
Pages: 8
DOI: 10.2174/187152010794728684
Price: $58