Neurological Disorders in Mice Lacking Glycogenes that are Mainly Expressed in Brain

Author(s): Hisashi Narimatsu.

Journal Name: CNS & Neurological Disorders - Drug Targets
(Formerly Current Drug Targets - CNS & Neurological Disorders)

Volume 5 , Issue 4 , 2006

Become EABM
Become Reviewer

Abstract:

At the present time, 160 human glycogenes encoding glycosyltransferases and sulfotransferases, which add sulfate to carbohydrates, have been cloned and analyzed for their substrate specificity. Mice have almost all genes orthologous to them, and some are specifically expressed in neuronal tissues. In this review, neurological disorders of mice deficient for the glycogenes that synthesize interesting carbohydrate epitopes in neuronal tissues are described and summarized.

Keywords: Glycogene, glycosyltransferase, sulfotransferase, ganglioside, HNK-1, Lewis X, polysialic acid, knockout mouse

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 5
ISSUE: 4
Year: 2006
Page: [441 - 444]
Pages: 4
DOI: 10.2174/187152706777950747
Price: $58