Abstract
At the present time, 160 human glycogenes encoding glycosyltransferases and sulfotransferases, which add sulfate to carbohydrates, have been cloned and analyzed for their substrate specificity. Mice have almost all genes orthologous to them, and some are specifically expressed in neuronal tissues. In this review, neurological disorders of mice deficient for the glycogenes that synthesize interesting carbohydrate epitopes in neuronal tissues are described and summarized.
Keywords: Glycogene, glycosyltransferase, sulfotransferase, ganglioside, HNK-1, Lewis X, polysialic acid, knockout mouse
CNS & Neurological Disorders - Drug Targets
Title: Neurological Disorders in Mice Lacking Glycogenes that are Mainly Expressed in Brain
Volume: 5 Issue: 4
Author(s): Hisashi Narimatsu
Affiliation:
Keywords: Glycogene, glycosyltransferase, sulfotransferase, ganglioside, HNK-1, Lewis X, polysialic acid, knockout mouse
Abstract: At the present time, 160 human glycogenes encoding glycosyltransferases and sulfotransferases, which add sulfate to carbohydrates, have been cloned and analyzed for their substrate specificity. Mice have almost all genes orthologous to them, and some are specifically expressed in neuronal tissues. In this review, neurological disorders of mice deficient for the glycogenes that synthesize interesting carbohydrate epitopes in neuronal tissues are described and summarized.
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Cite this article as:
Narimatsu Hisashi, Neurological Disorders in Mice Lacking Glycogenes that are Mainly Expressed in Brain, CNS & Neurological Disorders - Drug Targets 2006; 5 (4) . https://dx.doi.org/10.2174/187152706777950747
DOI https://dx.doi.org/10.2174/187152706777950747 |
Print ISSN 1871-5273 |
Publisher Name Bentham Science Publisher |
Online ISSN 1996-3181 |
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