Novel Treatments of Schizophrenia: Targeting the Neurotensin System

Author(s): B. Kinkead, C. B. Nemeroff.

Journal Name: CNS & Neurological Disorders - Drug Targets

Volume 5 , Issue 2 , 2006

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Abstract:

Evidence implicating neural circuits that utilize the neuropeptide transmitter neurotensin (NT) in the pathophysiology of schizophrenia and in the mechanism of action of antipsychotic drugs has previously been reviewed. The majority of evidence, taken together, supports the development of NT receptor agonists as novel antipsychotic drugs. This review comprehensively describes the NT receptor subtypes, discusses the development of NT receptor agonists and the behavioral effects of currently available NT receptor agonists. The compilation of data suggests that NT receptor agonists may represent a novel class of antipsychotic drugs for the treatment of schizophrenia.

Keywords: Antipsychotic drug, peptide, neuromedin N, xenin, schizophrenia

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Article Details

VOLUME: 5
ISSUE: 2
Year: 2006
Page: [205 - 218]
Pages: 14
DOI: 10.2174/187152706776359655
Price: $58

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