CNS & Neurological Disorders - Drug Targets

(Formerly Current Drug Targets - CNS & Neurological Disorders)

Stephen D. Skaper  
Department of Pharmaceutical and Pharmacological Sciences
University of Padova
Padova
Italy

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Neuropeptide Y: Role in Emotion and Alcohol Dependence

Author(s): R. Quirion, Y. Dumont and C. Carvajal

Affiliation: Scientific Director, DouglasHospital Research Centre, Institute of Neurosciences, Mental Health andAddiction, Canadian Institutes of Health Research (CIHR), 6875 LaSalleBlvd., Montreal, QC, Canada, H4H 1R3.

Abstract:

Neuropeptide Y (NPY) is considered to be an important neuromodulator in the regulation of emotional behavior. For example, NPY is consistently involved in anxiety-related behaviors and there is increasing support for a role of this peptide in mood disorders such as depression. Furthermore, recent evidence suggests that NPY has a significant role in the neurobiological response to alcohol, including alcohol consumption, dependence, and withdrawal. In addition, NPY is beginning to emerge as an important modulator in the etiology of alcoholism that is independent from the addictive and reinforcing properties of the traditional system commonly associated with dopamine and instead, is strongly associated with innate emotionality. The recent developments elucidating the role of NPY in emotion and alcohol dependence are reviewed and the potential of the NPY system as a novel therapeutic strategy in the treatment of anxiety, depression and alcohol-related disorders is examined.

Keywords: alcohol, depression, stress, anxiety, emotion, Neuropeptide Y, dependence, sedation

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Article Details

VOLUME: 5
ISSUE: 2
Page: [181 - 195]
Pages: 15
DOI: 10.2174/187152706776359592
Price: $58