COX-2 Inhibitors and Cardiovascular Events: Deja Vu Du Jour

Author(s): Thomas A. Doser, Bruce Culver, Jun Ren.

Journal Name: Vascular Disease Prevention

Volume 3 , Issue 3 , 2006

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Abstract:

Cyclooxygenase (COX)-2 inhibitors are effective therapeutic agents for arthritis and pain similar to nonspecific nonsteroidal anti-inflammatory drugs. However, clinical usage of COX-2 inhibitors has been jeopardized by their undesired cardiovascular complications including higher incidence of myocardial infarction, thrombosis and hypertension. One main concern is whether the reported cardiovascular effects of a given COX-2 inhibitor such as rofecoxib (Vioxx) are a "universal" effect applicable to all COX-2 inhibitors initially designed to reduce gastric adverse effect of nonselective COX inhibitors. This review was geared towards updating recent progress in cardiovascular risk related to prostaglandin inhibition resulting from COX-2 inhibitors. The emphasis is on findings in the last three to four years with only occasional references to earlier work. A number of clinical trials have been summarized and the jury is still out there as to whether the benefit outweighs the risk for COX-2 inhibition.

Keywords: COX-2 inhibitor, cardiovascular, risk, benefit

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Article Details

VOLUME: 3
ISSUE: 3
Year: 2006
Page: [217 - 221]
Pages: 5
DOI: 10.2174/1567270010603030217
Price: $58

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