S-Layer Proteins as Key Components of a Versatile Molecular Construction Kit for Biomedical Nanotechnology

Author(s): B. Schuster, D. Pum, M. Sara, U. B. Sleytr.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 6 , Issue 8 , 2006

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Abstract:

Surface (S)-layer proteins and S-layer fusion proteins incorporating functional sequences, self-assemble into monomolecular lattices on solid supports and on various lipid structures. Based on these S-layer proteins, supramolecular assemblies can be constructed which are envisaged for label-free detection systems, as affinity matrix, as anti-allergic immuno-therapeutics, as membrane protein-based screening devices, and as drug targeting and delivery systems.

Keywords: Crystalline surface layer proteins, artificial virus, biomimetics, bottom-up strategy, S-layer fusion protein, microspheres-based detoxification system, nanobiotechnology

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Article Details

VOLUME: 6
ISSUE: 8
Year: 2006
Page: [909 - 920]
Pages: 12
DOI: 10.2174/138955706777935026
Price: $58

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