Abstract
Exposure to hyperoxia ( > 95% O2) is a necessary therapeutic treatment used to maintain tissue oxygenation in patients with compromised lung function and decreased pulmonary gas exchange. Hyperoxia causes increased formation of reactive oxygen species (ROS), which accumulate in the cells of the lung resulting in cell death and compromised tissue function. Recent observations have demonstrated that different lung cell types respond differently to increased oxidative stress raising many questions about the cell-type restricted response of different pulmonary cell types. This review will focus on three main aspects of chronic oxidative stress in a cell-type specific manner: the role of antioxidant defenses, DNA repair, and apoptotic signaling.
Keywords: Anti-oxidants, apoptosis, DNA damage, hyperoxia, lung, reactive oxygen species
Current Respiratory Medicine Reviews
Title: Cell-Type Restricted Responses to Chronic Oxidative Stress
Volume: 2 Issue: 3
Author(s): Jason M. Roper and Michael A. O'Reilly
Affiliation:
Keywords: Anti-oxidants, apoptosis, DNA damage, hyperoxia, lung, reactive oxygen species
Abstract: Exposure to hyperoxia ( > 95% O2) is a necessary therapeutic treatment used to maintain tissue oxygenation in patients with compromised lung function and decreased pulmonary gas exchange. Hyperoxia causes increased formation of reactive oxygen species (ROS), which accumulate in the cells of the lung resulting in cell death and compromised tissue function. Recent observations have demonstrated that different lung cell types respond differently to increased oxidative stress raising many questions about the cell-type restricted response of different pulmonary cell types. This review will focus on three main aspects of chronic oxidative stress in a cell-type specific manner: the role of antioxidant defenses, DNA repair, and apoptotic signaling.
Export Options
About this article
Cite this article as:
Roper M. Jason and O'Reilly A. Michael, Cell-Type Restricted Responses to Chronic Oxidative Stress, Current Respiratory Medicine Reviews 2006; 2 (3) . https://dx.doi.org/10.2174/157339806778018944
DOI https://dx.doi.org/10.2174/157339806778018944 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
Call for Papers in Thematic Issues
Exposure to PM2.5 components is associated with respiratory diseases
Through continuous research on the relationship between risk factors and health, it has been found that air pollution, especially atmospheric particulate matter pollution, has become one of the main sources of global disease burden. From 1990 to 2022, the concentration of atmospheric particulate matter pollution has increased by more than ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
A New Application Route of Nitrofurantoin: Preparation and Characterization of Novel Transdermal Formulations
Current Drug Delivery Patterns of Expression of Viral and Cytokine Gene Transcripts During Mouse Polyoma Virus Infection
Combinatorial Chemistry & High Throughput Screening Understanding Recognition and Self-assembly in Biology using the Chemist´s Toolbox. Insight into Medicinal Chemistry
Current Topics in Medicinal Chemistry Herbal Resources to Combat a Progressive & Degenerative Nervous System Disorder- Parkinson’s Disease
Current Drug Targets Knockdown of C-C Chemokine Receptor 5 (CCR5) is Protective Against Cerebral Ischemia and Reperfusion Injury
Current Neurovascular Research Kv7 Channels as Targets for the Treatment of Pain
Current Pharmaceutical Design TGF-β : Titan of Lung Fibrogenesis
Current Enzyme Inhibition Editorial (Thematic Issue Cells and Gene Therapy - “Do You Like Green Eggs and Ham?”)
Current Gene Therapy 5-Lipoxygenase and Cyclooxygenase Inhibitory Dammarane Triterpenoid 1 from Borassus flabellifer Seed Coat Inhibits Tumor Necrosis Factor-α Secretion in LPSInduced THP-1 Human Monocytes and Induces Apoptosis in MIA PaCa-2 Pancreatic Cancer Cells
Anti-Cancer Agents in Medicinal Chemistry Blockade of Ser16-Hsp20 Phosphorylation Attenuates Neuroprotection Dependent Upon Bcl-2 and Bax
Current Neurovascular Research Hypersensitivity Reactions to Anticoagulant Drugs
Current Pharmaceutical Design Preface
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Calpain-Associated Proteolytic Regulation of the Stromal Microenvironment in Cancer
Current Pharmaceutical Design Potential Applications of Induced Pluripotent Stem Cells (iPSCs) in the Modeling of Gastrointestinal Disorders
Current Stem Cell Research & Therapy Clozapine Induced Eosinophilia in a Case of Schizoaffective Disorder
Current Psychopharmacology Dynamics of Toll-like Receptors Signaling in Skeletal Muscle Atrophy
Current Medicinal Chemistry Nitric Oxide and Dietary Factors: Part V Summary/Conclusion and References
Vascular Disease Prevention (Discontinued) Editorial (Hot Topic :Randomized Clinical Trials in Inflammatory Bowel Disease)
Reviews on Recent Clinical Trials The Causal Relationship Between Passive Smoking and Inflammation on the Development of Cardiovascular Disease: A Review of the Evidence
Inflammation & Allergy - Drug Targets (Discontinued) Editorial [Hot Topic: Interferon Alpha2 in the Treatment of Hematological Malignancies. Status and Perspectives (Guest Editor: Hans Carl Hasselbalch)]
Current Drug Targets