Current Respiratory Medicine Reviews

Joseph Varon  
The University of Texas Health Science Center
Houston, TX
USA

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Is There a Genetic Susceptibility to Bronchopulmonary Dysplasia?

Author(s): Anupama Shetty, Jeffrey R. Gruen, Vineet Bhandari.

Abstract:

Bronchopulmonary Dysplasia (BPD) continues to be a major problem despite advances in the management of the sick preterm. Current evidence supports a multifactorial etiology to this disease. Prematurity is the cardinal factor; others include pulmonary baro/volu trauma, hyperoxia, and inflammation. A clearer understanding of genetic susceptibility for BPD has recently emerged. Twin studies have shown that 53% of the variance for BPD is genetic. This article will attempt to review the published literature appraising the relationship between single nucleotide polymorphisms of putative causal genes and susceptibility to BPD. These studies, though small in size, spark interest in further genetic association studies to identify candidate genes that contribute to the diverse pathophysiology of BPD.

Keywords: Lung, single nucleotide polymorphisms, cytokines, preterm newborn

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Article Details

VOLUME: 2
ISSUE: 3
Year: 2006
Page: [253 - 262]
Pages: 10
DOI: 10.2174/157339806778018935
Price: $58