Antimicrobial Properties of Nuclear Diffusion Inhibitory Signal of HIV-1 Rev

Author(s): Nahoko Kobayashi, Tetsuhiko Yoshida.

Journal Name: Protein & Peptide Letters

Volume 13 , Issue 8 , 2006

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Abstract:

Nuclear Diffusion Inhibitory Signal (NIS) has been identified in human immunodeficiency virus type 1 (HIV- 1) Rev as a nuclear signal peptide which modulates nucleocytoplasmic protein trafficking and intracellular stability of the HIV-1 Rev. In this study, it was discovered that antimicrobial properties are inherent in the NIS. This is a significant finding that the NIS, which does not exist solely for self defense, in fact possesses antimicrobial properties.

Keywords: Nuclear diffusion inhibitory signal (NIS), antimicrobial peptide, minimum inhibitory concentration (MIC), antimicrobial activity, HIV-1 Rev

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Article Details

VOLUME: 13
ISSUE: 8
Year: 2006
Page: [805 - 806]
Pages: 2
DOI: 10.2174/092986606777841217
Price: $58

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