Antimicrobial Properties of Nuclear Diffusion Inhibitory Signal of HIV-1 Rev

Nahoko      Kobayashi; Tetsuhiko      Yoshida

Abstract

Nuclear Diffusion Inhibitory Signal (NIS) has been identified in human immunodeficiency virus type 1 (HIV- 1) Rev as a nuclear signal peptide which modulates nucleocytoplasmic protein trafficking and intracellular stability of the HIV-1 Rev. In this study, it was discovered that antimicrobial properties are inherent in the NIS. This is a significant finding that the NIS, which does not exist solely for self defense, in fact possesses antimicrobial properties.

Keywords: Nuclear diffusion inhibitory signal (NIS), antimicrobial peptide, minimum inhibitory concentration (MIC), antimicrobial activity, HIV-1 Rev

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Protein & Peptide Letters

Title: Antimicrobial Properties of Nuclear Diffusion Inhibitory Signal of HIV-1 Rev

Volume: 13 Issue: 8

Author(s): Nahoko Kobayashi and Tetsuhiko Yoshida

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Keywords: Nuclear diffusion inhibitory signal (NIS), antimicrobial peptide, minimum inhibitory concentration (MIC), antimicrobial activity, HIV-1 Rev

Abstract: Nuclear Diffusion Inhibitory Signal (NIS) has been identified in human immunodeficiency virus type 1 (HIV- 1) Rev as a nuclear signal peptide which modulates nucleocytoplasmic protein trafficking and intracellular stability of the HIV-1 Rev. In this study, it was discovered that antimicrobial properties are inherent in the NIS. This is a significant finding that the NIS, which does not exist solely for self defense, in fact possesses antimicrobial properties.

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Kobayashi Nahoko and Yoshida Tetsuhiko, Antimicrobial Properties of Nuclear Diffusion Inhibitory Signal of HIV-1 Rev, Protein & Peptide Letters 2006; 13 (8) . https://dx.doi.org/10.2174/092986606777841217