Detailed Molecular Understanding of Agonistic and Antagonistic Vitamin D Receptor Ligands

Author(s): Carsten Carlberg, Ferdinand Molnar.

Journal Name: Current Topics in Medicinal Chemistry

Volume 6 , Issue 12 , 2006

Become EABM
Become Reviewer


The vitamin D receptor (VDR) is an endocrine member of the nuclear receptor superfamily and binds the biologically most active vitamin D metabolite, 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3). The VDR ligandbinding domain is a molecular switch, since its ligand-triggered interactions with corepressor and coactivator proteins are the central molecular events of nuclear 1α,25(OH)2D3 signaling. 1α,25(OH)2D3 analogues have been developed with the goal to improve the biological profile of the natural hormone for a therapeutic application either in hyperproliferative diseases, such as psoriasis and different types of cancer, or in bone disorders, such as osteoporosis. Most of the analogues described to date are agonists, with a few having been identified as antagonists. Only the two side chain analogue Gemini and some of its derivatives act under restricted conditions as inverse agonists. In this review we discuss the molecular mechanisms of these different type of analogues based on crystal structure data, molecular dynamics simulations and biochemical assays.

Keywords: Nuclear receptor signaling, vitamin D, vitamin D analogues, vitamin D receptor, coactivator proteins, corepressor proteins

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2006
Page: [1243 - 1253]
Pages: 11
DOI: 10.2174/156802606777864908
Price: $58

Article Metrics

PDF: 3