High-Throughput Lipophilicity Screening of Opioid-Like Analgesics: Validation of Computational Methods by Means of RP-HPLC Analysis

Title: High-Throughput Lipophilicity Screening of Opioid-Like Analgesics: Validation of Computational Methods by Means of RP-HPLC Analysis

Volume: 3 Issue: 6

Author(s): O. Azzolina, S. Collina, D. Rossi, A. Carnevale Baraglia, S. Alcaro and A. Artese

Affiliation:

Keywords: Dialkylaminoalkylnaphthalenes, cycloaminoalkylnaphthalenes, opioid-like analgesics, log P, RP-HPLC, computational methods

Abstract: In the last five years we prepared and studied some dialkylaminoalkylnaphthalenes and cycloaminoalkylnaphthalenes with interesting opioid-like analgesic activity. In this paper we report on their lipophilicity evaluation combining computational and RP-HPLC experiments. A suitable computational method for the high-throughput log P screening was identified.

Cite this article as:

Azzolina O., Collina S., Rossi D., Carnevale Baraglia A., Alcaro S. and Artese A., High-Throughput Lipophilicity Screening of Opioid-Like Analgesics: Validation of Computational Methods by Means of RP-HPLC Analysis, Letters in Drug Design & Discovery 2006; 3 (6) . https://dx.doi.org/10.2174/157018006777805530