Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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High-Throughput Lipophilicity Screening of Opioid-Like Analgesics: Validation of Computational Methods by Means of RP-HPLC Analysis

Author(s): O. Azzolina, S. Collina, D. Rossi, A. Carnevale Baraglia, S. Alcaro, A. Artese.

Abstract:

In the last five years we prepared and studied some dialkylaminoalkylnaphthalenes and cycloaminoalkylnaphthalenes with interesting opioid-like analgesic activity. In this paper we report on their lipophilicity evaluation combining computational and RP-HPLC experiments. A suitable computational method for the high-throughput log P screening was identified.

Keywords: Dialkylaminoalkylnaphthalenes, cycloaminoalkylnaphthalenes, opioid-like analgesics, log P, RP-HPLC, computational methods

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Article Details

VOLUME: 3
ISSUE: 6
Year: 2006
Page: [413 - 418]
Pages: 6
DOI: 10.2174/157018006777805530
Price: $58