Current Bioinformatics

Yi-Ping Phoebe Chen
Department of Computer Science and Information Technology
La Trobe University
Melbourne
Australia

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Advances in the Discovery of cis-Regulatory Elements

Author(s): Youlian Pan.

Abstract:

Discovery of transcription regulatory elements has been an enormous challenge, both to biologists and computational scientists. Over the last three decades, significant progress has been achieved by various laboratories around the world. Earlier, laborious experimental methods were used to detect one or handful of elements at a time. With recent advances in DNA sequencing technology, many completed genomes became available. High throughput biological techniques and computational methods emerged. Comparative genomic approaches and their integration with microarray gene expression data provided promising results. In this review, we discuss the development of technology to decipher the complex transcription regulation system with a focus on the discovery of cis-regulatory elements in eukaryotes.

Keywords: cis-regulatory elements, motifs, transcription factor binding sites, transcriptional regulation, gene expression, transcription factor

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Article Details

VOLUME: 1
ISSUE: 3
Year: 2006
Page: [321 - 336]
Pages: 16
DOI: 10.2174/157489306777828026
Price: $58