Neurotrophic Effects of the Peptide NAP: A Novel Neuroprotective Drug Candidate

Author(s): Illana Gozes, Irit Spivak-Pohis.

Journal Name: Current Alzheimer Research

Volume 3 , Issue 3 , 2006

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Abstract:

This short review outlines the scientific progression from the neuropeptide vasoactive intestinal peptide as a neuroprotective agent that acts through glial cells to increase and modulate the synthesis and secretion of novel neuroprotective substances. Recent development in the studies on activity-dependent neuroprotective protein (ADNP) and activitydependent neurotrophic factor (ADNF) and short peptide derivatives of these proteins, ADNF-9 and NAP suggest that these peptides are neurotrophic and promote neurite outgrowth. These short peptides hold promise in future neuroprotective/ neurotrophic drug development. Clinical development of NAP is currently in progress by Allon Therapeutics, Inc.

Keywords: Vasoactive intestinal peptide (VIP), ciliary neurotrophic factor (CNTF), ADNF-9, neuroprotective, expression

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Article Details

VOLUME: 3
ISSUE: 3
Year: 2006
Page: [197 - 199]
Pages: 3
DOI: 10.2174/156720506777632790
Price: $58

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