Current Stem Cell Research & Therapy

Anthony Atala  
Wake Forest University School of Medicine,
Medical Center Boulevard
Winston Salem, NC 27157


Mechanisms of Neural Stem Cell Fate Determination: Extracellular Cues and Intracellular Programs

Author(s): Masahiko Abematsu, Ian Smith, Kinichi Nakashima.


Multipotent neural stem cells (NSC) possess the ability to self-renew and to generate the three major central nervous system (CNS) cell types: neurons, astrocytes and oligodendrocytes. However, the molecular mechanisms that control NSC fate specification are not yet fully understood. Recent studies have provided evidence that soluble protein mediators such as cytokines and transcriptional factors play critical roles in cell fate determination. Furthermore, it has become apparent that epigenetic gene regulation plays an important intracellular role as cell-intrinsic programs in the specification of cell lineages. In this review, we focus on recent progress that addresses the mechanisms of NSC fate specification and their possible contribution in the field of regenerative medicine.

Keywords: Neural stem cells, Cytokines, Epigenetics, Methylation, Acetylation, Spinal cord injury

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Article Details

Year: 2006
Page: [267 - 277]
Pages: 11
DOI: 10.2174/157488806776956887
Price: $58