Structural Properties of the NMDA Receptor and the Design of Neuroprotective Therapies

Author(s): A. M. Gerber, M. L. Vallano.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 6 , Issue 7 , 2006

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Abstract:

NMDA receptors are linked to neuronal loss in stroke and neurodegeneration because their activation can triggerexcitotoxic Ca2+ dysregulation. Accordingly, NMDA receptor antagonists are neuroprotective, providing a rationale fortheir clinical application. However, side effects often outweigh benefits. Herein we highlight structural properties inreceptors that are used in drug development.

Keywords: Glutamate, excitotoxicity, NMDA receptor, therapeutics, neurodegeneration, drug design

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Article Details

VOLUME: 6
ISSUE: 7
Year: 2006
Page: [805 - 815]
Pages: 11
DOI: 10.2174/138955706777698651
Price: $58