Abstract
NMDA receptors are linked to neuronal loss in stroke and neurodegeneration because their activation can triggerexcitotoxic Ca2+ dysregulation. Accordingly, NMDA receptor antagonists are neuroprotective, providing a rationale fortheir clinical application. However, side effects often outweigh benefits. Herein we highlight structural properties inreceptors that are used in drug development.
Keywords: Glutamate, excitotoxicity, NMDA receptor, therapeutics, neurodegeneration, drug design
Mini-Reviews in Medicinal Chemistry
Title: Structural Properties of the NMDA Receptor and the Design of Neuroprotective Therapies
Volume: 6 Issue: 7
Author(s): A. M. Gerber and M. L. Vallano
Affiliation:
Keywords: Glutamate, excitotoxicity, NMDA receptor, therapeutics, neurodegeneration, drug design
Abstract: NMDA receptors are linked to neuronal loss in stroke and neurodegeneration because their activation can triggerexcitotoxic Ca2+ dysregulation. Accordingly, NMDA receptor antagonists are neuroprotective, providing a rationale fortheir clinical application. However, side effects often outweigh benefits. Herein we highlight structural properties inreceptors that are used in drug development.
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Cite this article as:
Gerber M. A. and Vallano L. M., Structural Properties of the NMDA Receptor and the Design of Neuroprotective Therapies, Mini-Reviews in Medicinal Chemistry 2006; 6 (7) . https://dx.doi.org/10.2174/138955706777698651
DOI https://dx.doi.org/10.2174/138955706777698651 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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