Myostatin: Biology and Clinical Relevance
Gilles Carnac, Stephanie Ricaud, Barbara Vernus and Anne Bonnieu
Affiliation: INRA, UMR 866-Differen-ciation Cellulaire et Croissance, 34060 Montpellier Cedex 1, France.
Myostatin is a negative regulator of muscle mass. Important advances in our understanding of thecomplex biology of this factor have revealed the therapeutic potential of antagonizing the myostatin pathway. Herewe present the rationale for evaluating anti-myostatin therapies in human muscle-wasting disorders.
Keywords: Myostatin, Muscle, Adipose tissue, Rhabdomyosarcoma, Myostatin antagonism, Myostatin processing and signaling, therapeutic approaches
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