Mini-Reviews in Medicinal Chemistry

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Structural and Functional Properties of NAD Kinase, a Key Enzyme in NADP Biosynthesis

Author(s): Giulio Magni, Giuseppe Orsomando, Nadia Raffaelli.

Abstract:

NAD kinase is an essential enzyme, which plays a key role in cellular energy and signal transduction systems. Inthis report, the recent studies on the features of bacterial and human NAD kinases are summarized. They include detailedkinetic and structural analyses and highlight important differences, which could be exploited for the design of novelselective antimicrobial drugs.

Keywords: NADP biosynthesis, pyridine dinucleotides, recombinant protein, antimicrobial agents, kinetic analysis

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Article Details

VOLUME: 6
ISSUE: 7
Year: 2006
Page: [739 - 746]
Pages: 8
DOI: 10.2174/138955706777698688
Price: $58