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Mini-Reviews in Medicinal Chemistry
ISSN (Print): 1389-5575
ISSN (Online): 1875-5607
VOLUME: 6
ISSUE: 7
DOI: 10.2174/138955706777698688      Price:  $58









Structural and Functional Properties of NAD Kinase, a Key Enzyme in NADP Biosynthesis

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Author(s): Giulio Magni, Giuseppe Orsomando and Nadia Raffaelli
Pages 739-746 (8)
Abstract:
NAD kinase is an essential enzyme, which plays a key role in cellular energy and signal transduction systems. Inthis report, the recent studies on the features of bacterial and human NAD kinases are summarized. They include detailedkinetic and structural analyses and highlight important differences, which could be exploited for the design of novelselective antimicrobial drugs.
Keywords:
NADP biosynthesis, pyridine dinucleotides, recombinant protein, antimicrobial agents, kinetic analysis
Affiliation:
Istituto di Biotecnologie Biochimiche, Universita Politecnica delle Marche, Via Ranieri, 60131Ancona, Italy.