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Protein & Peptide Letters
ISSN (Print): 0929-8665
ISSN (Online): 1875-5305
VOLUME: 13
ISSUE: 7
DOI: 10.2174/092986606777790601      Price:  $58









Key Residues Involved in Hsp70 Regulatory Activity and Affect of Co-Chaperones on Mechanism of Action

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Author(s): Yusuf Tutar
Pages 693-698 (6)
Abstract:
Hsp70 proteins assist refolding of polypeptides in an ATP dependent manner. Crystal structure of intact Hsp70 protein has not been determined yet however, structures of its two domains were solved separately. Allostery between ATPase domain and peptide-binding domain facilitates unfolded substrate processing. To elucidate function of key residues and affect of other factors involved in this allosteric mechanism, a biochemical study was undertaken.
Keywords:
Stability, Hsp70, Ydj1
Affiliation:
Chemistry Department, Faculty of Science, Cumhuriyet University, Sivas 58140, Turkey.